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Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

Daniel A. Everson, Ruja Shrestha and Daniel J. Weix*

*Department of Chemistry, University of Rochester, Rochester, New York 14627, Email: daniel.weixrochester.edu

D. A. Everson, R. Shrestha, D. J. Weix, J. Am. Chem. Soc., 2010, 132, 920-921.

DOI: 10.1021/ja9093956 (free Supporting Information)


Abstract

An efficient, nickel-catalyzed direct reductive cross-coupling of equimolar amounts of alkyl halides with aryl halides in the presence of manganese is generally high-yielding, highly functional-group-tolerant, and easy to perform. The reaction appears to avoid the formation of intermediate organomanganese species, and a synergistic effect was found when a mixture of two ligands was employed.

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Synthesis of Functionalized Dialkyl Ketones from Carboxylic Acid Derivatives and Alkyl Halides

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Key Words

Arenes, Manganese


ID: J48-Y2010-0220