Silicon Tetrachloride Catalyzed Aza-Michael Addition of Amines to Conjugated Alkenes under Solvent-Free Conditions

Najmedin Azizi*, Roya Baghi, Hossein Ghafuri, Mohammad Bolourtchian, Mohammad Hashemi

*Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran, Email: aziziccerci.ac.ir

N. Azizi, R. Baghi, H. Ghafuri, M. Boloutchian, M. Hashemi, Synlett, 2010, 379-382.

DOI: 10.1055/s-0029-1219195

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Abstract

An efficient and very simple conjugate addition of aromatic and aliphatic amines to α,β-unsaturated carbonyl compounds under solvent-free conditions in the presence of catalytic amount of silicon tetrachloride gave the corresponding Michael adducts with very good yields.

see article for more examples

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LiClO₄ Accelerated Michael addition of amines to α,β-unsaturated olefins under solvent-free conditions

N. Azizi, M. R. Saidi, Tetrahedron, 2004, 60, 383-387.

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Key Words

aromatic amines, conjugate additions, silicon tetrachloride, β-aminocarbonyl compounds, Michael Addition

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ID: J60-Y2010-0260