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Au/Ag-Cocatalyzed Aldoximes to Amides Rearrangement under Solvent- and Acid-Free Conditions

Rubén S. Ramón, Johann Bosson, Silvia Díez-González, Nicolas Marion and Steven P. Nolan*

*School of Chemistry, University of St. Andrews, St. Andrews KY16 9ST, UK, Email: snolanst-andrews.ac.uk

R. S. Ramón, J. Bosson, S. Díez-González, N. Marion, S. P. Nolan, J. Org. Chem., 2010, 75, 1197-1202.

DOI: 10.1021/jo902461a (free Supporting Information)


Abstract

A gold/silver-cocatalyzed conversion of aldoximes into primary amides proceeds under neat and acid-free conditions and allows the conversion of a range of aldoximes. The reaction is a rare example of cooperative catalysis involving well-defined gold species.

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Key Words

Beckmann Rearrangement


ID: J42-Y2010-0440