In situ Formation of NOx and Br Anion for Aerobic Oxidation of Benzylic Alcohols without Transition Metal
Guanyu Yang*, Wei Wang, Weimin Zhu, Cunbin An, Xinqin Gao, Maoping Song*
*Department of Chemistry, Zhengzhou University, 75 Daxue Road, Zhengzhou 450052, P. R. of China, Email: yangguanyuzzu.edu.cn, mpsong9350zzu.edu.cn
G. Yang, W. Wang, W. Zhu, C. An, X. Gao, M. Song, Synlett, 2010, 437-440.
The reaction of KBrO3 and NH2OH • HCl in situ generates NOx and Br anion, which allows in the presence of 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO) an activation of dioxygen to oxidize various benzylic alcohols quantitatively to their corresponding carbonyl compounds under mild conditions.
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