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Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents

Mao Chen, Xiaolong Zheng, Wenqing Li, Jun He and Aiwen Lei*

*College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China, Email: aiwenleiwhu.edu.cn

M. Chen, X. Zheng, W. Li, J. He, A. Lei, J. Am. Chem. Soc., 2010, 132, 4101-4103.

DOI: 10.1021/ja100630p (free Supporting Information)


Abstract

Terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature with air as the oxidant. CO was found to be critical in gaining high chemical yields and selectivities. Good yields were obtained for a wide range of alkynes and alkylzinc reagents.

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Key Words

Alkynes, Oxygen


ID: J48-Y2010-0640