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Copper-Catalyzed Chlorination of Functionalized Arylboronic Acids

Hong Wu and John Hynes, Jr.*

*Discovery Chemistry, Bristol-Myers Squibb Company, PO Box 4000, Princeton New Jersey 08543, Email: john.hynesbms.com

H. Wu, J. Hynes, Jr., Org. Lett., 2010, 12, 1192-1195.

DOI: 10.1021/ol9029337 (free Supporting Information)


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Abstract

A mild, efficient, Cu(I)-catalyzed method for the synthesis of aryl chlorides from arylboronic acids is particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient in the absence of Cu catalysis.

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Key Words

aryl chlorides, N-Chlorosuccinimide


ID: J54-Y2010-0730