A Concise Synthesis of Substituted Thiourea Derivatives in Aqueous Medium
Mahagundappa R. Maddani and Kandikere R. Prabhu*
*Department of Organic Chemistry, Indian Institute of
Science, Bangalore 560 012, Karnataka, India, Email: prabhu
orgchem.iisc.ernet.in
M. R. Maddani, K. R. Prabhu, J. Org. Chem., 2010, 75, 2327-2332.
DOI: 10.1021/jo1001593
Abstract
A simple condensation between amines and carbon disulfide in aqueous medium allows an efficient synthesis of symmetrical and unsymmetrical substituted thiourea derivatives. This protocol works smoothly with aliphatic primary amines to afford various di- and trisubstituted thiourea derivatives.
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Key Words
Thiourea Derivatives, Green Chemistry
ID: J42-Y2010-0850
