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Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes

Senthilkumar Muthaiah, Subhash Chandra Ghosh, Joo-Eun Jee, Cheng Chen, Jian Zhang and Soon Hyeok Hong*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore, Email:

S. Muthaiah, S. C. Ghosh, J.-E. Jee, C. Chen, J. Zahng, S. H. Hong, J. Org. Chem., 2010, 75, 3002-3006.

DOI: 10.1021/jo100254g (free Supporting Information)


An in situ generated catalyst from readily available RuH2(PPh3)4, an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines.

see article for more examples

Ruthenium-Catalyzed Redox-Neutral and Single-Step Amide Synthesis from Alcohol and Nitrile with Complete Atom Economy

B. Kang, Z. Fu, S. H. Hong, J. Am. Chem. Soc., 2013, 135, 11704-11707.

Key Words

Amides, Oxidation

ID: J42-Y2010-1190