Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me₃SiCF₃

Lingling Chu and Feng-Ling Qing*

*Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, Email: flqmail.sioc.ac.cn

L. Chu, F.-L. Qing, J. Am. Chem. Soc., 2010, 132, 7262-7263.

DOI: 10.1021/ja102175w

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Abstract

The nucleophilic trifluoromethylating reagent Me₃SiCF₃ enables an efficient copper-mediated trifluoromethylation of terminal alkynes. Various functionalities were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.

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Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane

X. Jiang, L. Chu, F.-L. Qing, J. Org. Chem., 2012, 77, 1251-1257.

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Key Words

trifluoromethyl alkynes

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ID: J48-Y2010-3610