Air-Stable Secondary Phosphine Oxide or Chloride (Pre)Ligands for Cross-Couplings of Unactivated Alkyl Chlorides
Lutz Ackermann*, Anant R. Kapdi and Carola Schulzke
*Institut für Organische und Biomolekulare Chemie and
Institut für Anorganische Chemie, Georg-August-Universitaet, Tammannstrasse 2,
37077 Goettingen, Germany, Email: lutz.ackermann
chemie.uni-goettingen.de
L. Ackermann, A. R. Kapdi, C. Schulzke, Org. Lett., 2010, 12, 2298-2301.
DOI: 10.1021/ol100658y
see article for more reactions
Abstract
Palladium complexes derived from air-stable secondary phosphine oxides or chlorides enabled challenging Kumada-Corriu cross-couplings of unactivated alkyl chlorides bearing β-hydrogens and proved applicable to transformations of alkyl-substituted organometallics.
see article for more examples
Air-Stable PinP(O)H as Preligand for Palladium-Catalyzed Kumada Couplings of Unactivated Tosylates
L. Ackermann, A. Althammer, Org. Lett., 2006, 8, 3457-3460.
Key Words
Kumada Coupling, Negishi Coupling, Arenes
ID: J54-Y2010-1430
