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Air-Stable Secondary Phosphine Oxide or Chloride (Pre)Ligands for Cross-Couplings of Unactivated Alkyl Chlorides

Lutz Ackermann*, Anant R. Kapdi and Carola Schulzke

*Institut für Organische und Biomolekulare Chemie and Institut für Anorganische Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany, Email: lutz.ackermannchemie.uni-goettingen.de

L. Ackermann, A. R. Kapdi, C. Schulzke, Org. Lett., 2010, 12, 2298-2301.

DOI: 10.1021/ol100658y (free Supporting Information)



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Abstract

Palladium complexes derived from air-stable secondary phosphine oxides or chlorides enabled challenging Kumada-Corriu cross-couplings of unactivated alkyl chlorides bearing β-hydrogens and proved applicable to transformations of alkyl-substituted organometallics.

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Air-Stable PinP(O)H as Preligand for Palladium-Catalyzed Kumada Couplings of Unactivated Tosylates

L. Ackermann, A. Althammer, Org. Lett., 2006, 8, 3457-3460.


Key Words

Kumada Coupling, Negishi Coupling, Arenes


ID: J54-Y2010-1430