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CuH-Catalyzed Enantioselective 1,2-Reductions of α,β-Unsaturated Ketones

Ralph Moser, Žarko V. Bošković, Christopher S. Crowe and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu

R. Moser, Ž. V. Bošković, C. S. Crowe, B. H. Lipshutz, J. Am. Chem. Soc., 2010, 132, 7852-7853.

DOI: 10.1021/ja102689e (free Supporting Information)



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Abstract

Asymmetric ligand-accelerated catalysis by copper hydride allows the synthesis of valued nonracemic allylic alcohols in very good yields.

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Key Words

1,2-Reduction, Silanes, Copper Hydride


ID: J48-Y2010-1610