Iridium/Chiral Diene-Catalyzed Asymmetric 1,6-Addition of Arylboroxines to α,β,γ,δ-Unsaturated Carbonyl Compounds

Takahiro Nishimura*, Yuichi Yasuhara, Takahiro Sawano and Tamio Hayashi*

*Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan, Email: tnishikuchem.kyoto-u.ac.jp, thayashikuchem.kyoto-u.ac.jp

T. Nishimura, Y. Yashuhara, T. Sawano, T. Hayashi, J. Am. Chem. Soc., 2010, 132, 7872-7873.

DOI: 10.1021/ja1034842

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Abstract

An iridium/chiral diene complex enabled a catalytic, asymmetric 1,6-addition of arylboroxines to α,β,γ,δ-unsaturated carbonyl compounds to give δ-arylated carbonyl compounds in high yields with excellent enantioselectivity.

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Highly Selective 1,6-Addition of Aryl Boronic Acids to α,β,γ,δ-Unsaturated Carbonyl Compounds Catalyzed by an Iridium Complex

T. Nishimura, Y. Yasuhara, T. Hayashi, Angew. Chem. Int. Ed., 2006, 45, 5164-5166.

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Key Words

1,6-Additions, Arenes

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ID: J48-Y2010-1630