An Efficient Transformation from Benzyl or Allyl Halides to Aryl and Alkenyl Nitriles
Wang Zhou, Jiaojiao Xu, Liangren Zhang and Ning Jiao*
*State Key Laboratory of Natural and Biomimetic Drugs, School
of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191,
China, Email: jiaoning
bjmu.edu.cn
W. Zhou, J. Xu, L. Zhang, N. Jiao, Org. Lett., 2010, 12, 2888-2891.
DOI: 10.1021/ol101094u
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Abstract
A tandem TBAB-catalyzed substitution and a subsequent novel oxidative rearrangement allow the synthesis of aryl or alkenyl nitriles from benzyl and allyl halides. The broad reaction scope and the mild conditions may make these methods of use in organic synthesis.
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Key Words
ID: J54-Y2010-1770
