Microwave-Assisted, One-Pot Reaction of Pyridines, α-Bromoketones and Ammonium Acetate: An Efficient and Simple Synthesis of Imidazo[1,2-a]-pyridines
Mehdi Adib*, Ali Mohamadi, Ehsan Sheikhi, Samira Ansari, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science,
University of Tehran, PO Box 14155-6455, Tehran, Iran, Email: madib
khayam.ut.ac.ir
M. Adib, A. Mohamadi, E. Sheikhi, S. Ansari, H. R. Bijanzadeh, Synlett, 2010, 1606-1608.
DOI: 10.1055/s-0029-1219962
Abstract
N-Phenacylpyridinium bromides, which were prepared in situ from the addition of pyridines to α-bromoketones, undergo nucleophilic addition of ammonium acetate under microwave irradiation and solvent-free conditions to afford the corresponding imidazo[1,2-a]pyridines in excellent yields.
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Key Words
imidazo[1,2-a]pyridines, α-bromoketones, ammonium acetate, microwave synthesis, solvent-free synthesis, cyclizations, heterocycles
ID: J60-Y2010-1790
