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Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of α-Cyano and α-Nitro Substituted Acetophenones

Omid Soltani, Martin A. Ariger, Henar Vázquez-Villa and Erick M. Carreira*

*Laboratorium für organische Chemie, ETH Zürich, Hönggerberg, Switzerland, Email: carreiraorg.chem.ethz.ch

O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett., 2010, 12, 2893-2895.

DOI: 10.1021/ol1008894 (free Supporting Information)


Abstract

An iridium-catalyzed, chemoselective, asymmetric transfer hydrogenation of α-substituted acetophenones using formic acid as reductant can be performed in water and open to air.

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Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of (E)-β,β-Disubstituted Nitroalkenes

O. Soltani, M. A. Ariger, E. M. Carreira, Org. Lett., 2009, 11, 4196-4198.


Key Words

reduction of carbonyl compounds, formic acid, β-cyanohydrins, green chemistry


ID: J54-Y2010-1800