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Rhodium-Catalyzed Arylzincation of Terminal Allenes Providing Allylzinc Reagents and Its Application to Versatile Three-component Coupling Reaction

Yuji Yoshida, Kei Murakami, Hideki Yorimitsu* and Koichiro Oshima*

*Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Email: yorikuchem.kyoto-u.ac.jp, oshimaorgrxn.mbox.media.kyoto-u.ac.jp

Y. Yoshida, K. Murakami, H. Yorimitsu, K. Oshima, J. Am. Chem. Soc., 2010, 132, 8878-8879.

DOI: 10.1021/ja102303s (free Supporting Information)



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Abstract

Rhodium-catalyzed regioselective arylzincation of terminal allenes affords synthetically useful functionalized allylzinc reagents, which can be protonated or react with various electrophiles such as carbonyl compounds and acetonitrile.

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Key Words

Olefination, Ketones, Multicomponent Reactions


ID: J48-Y2010-1810