Improved Palladium-Catalysed Synthesis of α-Benzyl-β-keto Ester

Nicholas J. Bennett*, Anne Goldby, Rachel Pringle

*Chemistry Department, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK, Email: nicholas.bennettastrazeneca.com

N. J. Bennett, A. Goldby, R. Pringle, Synlett, 2010, 1688-1690.

DOI: 10.1055/s-0030-1258095

---

Abstract

An improved Heck reaction allows the synthesis of various α-benzyl-β-keto esters from aryl bromides and Baylis-Hillman adducts for use in the preparation of new pharmaceutical agents.

see article for more examples

---

---

Key Words

palladium, Heck reaction, arylation, Baylis-Hillman adducts, α-benzyl-β-keto ester

---

ID: J60-Y2010-1840