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Preparation of Tetrasubstituted Furans via Intramolecular Wittig Reactions with Phosphorus Ylides as Intermediates

Tzu-Ting Kao, Siang-en Syu, Yi-Wun Jhang and Wenwei Lin*

*Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China, Email: wenweilinntnu.edu.tw

T.-T. Kao, S.-e. Syu, Y.-W. Jhang, W. Li, Org. Lett., 2010, 12, 3066-3069.

DOI: 10.1021/ol101080q (free Supporting Information)


Abstract

A broad range of highly functional furans can be efficiently generated from Michael acceptors, tributylphosphine, and acyl chlorides in one step at room temperature in good yields. The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

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Key Words

Furans


ID: J54-Y2010-1880