Chemistry of sulfonylmethyl isocyanides. 13. A general one-step synthesis of nitriles from ketones using tosylmethyl isocyanide. Introduction of a one-carbon unit
Otto H. Oldenziel, Daan Van Leusen, Albert M. Van Leusen*
*Department of Organic Chemistry, Groningen University, Nijenborgh 16, 9747 AG Groningen, The Netherlands
O. H. Oldenziel, D. Van Leusen, A. M. Van Leusen, J. Org. Chem., 1977, 42, 3114-3118.
DOI: 10.1021/jo00439a002
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Abstract
Tosylmethyl isocyanide allows an efficient conversion of ketones into nitriles by adding one carbon unit to a ketone without formation of an α-hydroxy group. The synthesis of nitriles is applicable to a broad range of ketones.
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Key Words
ID: J42-Y1977-0190