Solution-phase parallel oxazole synthesis with TosMIC
Bheemashankar A. Kulkarnia and Arun Ganesan*
*Chemistry, University of Southampton, Highfield, Southampton, UK, SO17 1BJ, Email: a.ganesansoton.ac.uk
B. A. Kulkarnia, A. Ganesan, Tetrahedron Lett., 1999, 40, 5637-5638.
A quaternary ammonium hydroxide ion exchange resin catalyzes the reaction of p-tolylsulfonylmethyl isocyanide (TosMIC) with aromatic aldehydes to give 5-aryloxazoles. The base and the p-tolylsulfinic acid byproduct can be removed by simple filtration, resulting in oxazoles in high yield and purity.
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