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Facile Conversion of Thioamides into the Corresponding Amides in the Presence of Tetrabutylammonium Bromide

Kiyofumi Inamoto*, Mitsugu Shiraishi, Kou Hiroya, Takayuki Doi*

*Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan, Email: inamotomail.pharm.tohoku.ac.jp, doi_takamail.pharm.tohoku.ac.jp

K. Inamoto, M. Shiraishi, K. Hiroya, T. Doi, Synthesis, 2010, 3087-3090.

DOI: 10.1055/s-0030-1258154


Abstract

Desulfurization of thioamides was accomplished using a semicatalytic amount of Bu4NBr. The corresponding amides were obtained in high yields, with good functional group compatibility.


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Key Words

desulfurization, thioamides, amides, tetrabutylammonium bromide - thioketones


ID: J66-Y2010-2560