Asymmetric Synthesis of Indolines by Catalytic Enantioselective Reduction of 3H-Indoles
Magnus Rueping*, Claus Brinkmann, Andrey P. Antonchick and Iuliana Atodiresei
*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany, Email: magnus.ruepingrwth-aachen.de
M. Rueping, C. Brinkmann, A. P. Antonchick, I. Atoresei, Org. Lett., 2010, 12, 4604-4607.
DOI: 10.1021/ol1019234 (free Supporting Information)
A Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source enables an efficient synthesis of various optically active indolines with high enantioselectivities.
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