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Efficient Copper(II) Acetate Catalyzed Homo- and Heterocoupling of Terminal Alkynes at Ambient Conditions

Kaluvu Balaraman, Venkitasamy Kesavan*

*Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India, Email: vkesavaniitm.ac.in

K. Balaraman, V. Kesavan, Synthesis, 2010, 3461-3466.

DOI: 10.1055/s-0030-1258199



Abstract

Symmetrical 1,3-diynes were obtained in quantitative yields using the copper(II) acetate catalyzed homocoupling of terminal alkynes in the presence of a stoichiometric amount of piperidine at 25C under aerobic conditions. Facile syntheses of unsymmetric 1,3-diynes by heterocoupling terminal alkynes were also accomplished in very good yields under the reported reaction conditions.

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Key Words

terminal alkynes, copper(II) acetate, piperidine, homocoupling, heterocoupling, 1,3-diynes, Glaser Coupling


ID: J66-Y2010-2950