Efficient Copper(II) Acetate Catalyzed Homo- and Heterocoupling of Terminal Alkynes at Ambient Conditions
Kaluvu Balaraman, Venkitasamy Kesavan*
*Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India, Email: vkesavaniitm.ac.in
K. Balaraman, V. Kesavan, Synthesis, 2010, 3461-3466.
Symmetrical 1,3-diynes were obtained in quantitative yields using the copper(II) acetate catalyzed homocoupling of terminal alkynes in the presence of a stoichiometric amount of piperidine at 25°C under aerobic conditions. Facile syntheses of unsymmetric 1,3-diynes by heterocoupling terminal alkynes were also accomplished in very good yields under the reported reaction conditions.
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