Palladium-Catalyzed Propargylic Substitution with Phosphorus Nucleophiles: Efficient, Stereoselective Synthesis of Allenylphosphonates and Related Compounds
Marcin Kalek, Tommy Johansson, Martina Jezowska and Jacek Stawinski*
*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, Email: jsorgan.su.se
M. Kalek, T. Johansson, M. Jezowska, J. Stawinski, Org. Lett., 2010, 12, 4702-4704.
DOI: 10.1021/ol102121j (free Supporting Information)
A new, efficient method based on a palladium(0)-catalyzed reaction of propargylic derivatives with various phosphorus nucleophiles produces allenylphosphonates and their analogues with defined stereochemistry in the allenic and the phosphonate moiety.
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