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Iron-Facilitated Direct Oxidative C-H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles

Chong Qin and Ning Jiao*

*State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China, Email: jiaoningbjmu.edu.cn

C. Qin, N. Jiao, J. Am. Chem. Soc., 2010, 132, 15893-15895.

DOI: 10.1021/ja1070202 (free Supporting Information)


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Abstract

An inexpensive homogeneous iron catalyst enables a direct approach to alkenyl nitriles from allylarenes or alkenes. Three C-H bond cleavages occur under the mild conditions during this process, involving the cleavage of the allyl C(sp3)-H bond as the rate-determining step.

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Key Words

Nitriles, α,β-unsaturated compounds, DDQ


ID: J48-Y2010-3130