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A Multiligand Based Pd Catalyst for C-N Cross-Coupling Reactions

Brett P. Fors and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu

B. P. Fors, S. L. Buchwald, J. Am. Chem. Soc., 2010, 132, 15914-15917.

DOI: 10.1021/ja108074t (free Supporting Information)


Abstract

A multiligand Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.

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Key Words

Buchwald-Hartwig Coupling


ID: J48-Y2010-3210