Direct Addition of Functionalized Organozinc Reagents to Carbon Dioxide, Ketones, and Aldehydes in the Presence of MgCl₂

Sebastian Bernhardt, Albrecht Metzger, Paul Knochel*

*Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany, Email: Paul.Knochelcup.uni-muenchen.de

S. Bernhardt, A. Metzger, P. Knochel, Synthesis, 2010, 3802-3810.

DOI: 10.1055/s-0030-1258314

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Abstract

A variety of functionalized organozinc reagents undergo smooth addition reactions at ambient temperature to carbonyl compounds and carbon dioxide in the presence of stoichiometric amounts of MgCl₂. Several reactions were performed on a large scale.

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Key Words

organozinc reagents, magnesium chloride, carbon dioxide, phenylacetic acid derivatives, addition reactions, alcohols, benzylic alcohols, carboxylic acids

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ID: J66-Y2010-3230