An Efficient Method for Aryl Nitro Reduction and Cleavage of Azo Compounds Using Iron Powder/Calcium Chloride
S. Chandrappa, K. Vinaya, T. Ramakrishnappa, K. S. Rangappa*
*Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India, Email: rangappakschemistry.uni-mysore.ac.in
S. Chandrappa, T. Vinaya, T. Ramakrishnappa, K. S. Rangappa, Synlett, 2010, 3019-3022.
An efficient Fe/CaCl2 system enables the reduction of nitroarenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation in the presence of sensitive functional groups including halides, carbonyl, aldehyde, acetyl, nitrile, and ester substituents with excellent yields. The simple experimental procedure and easy purification make the protocol advantageous.
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