A Novel Approach to 1-Monosubstituted 1,2,3-Triazoles by a Click Cycloaddition/Decarboxylation Process
Mei Xu, Chunxiang Kuang*, Zhuo Wang, Qing Yang, Yubo Jiang
*Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China, Email: kuangcxtongji.edu.cn
M. Xu, C. Kuang, Z. Wang, Q. Yang, Y. Jiang, Synthesis, 2011, 223-228.
A synthesis of 1-monosubstituted 1,2,3-triazoles was achieved using azides and propiolic acid by copper-catalyzed click cycloaddition/decarboxylation in N,N-dimethylformamide at room temperature or 60˚C in good yields. The reaction conditions were found to be successful for aryl and vinyl azide reactants and tolerate various functionalities.
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Y. Jiang, C. Kuang, Q. Yang, Synlett, 2009, 3163-3166.