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An Extremely Active and General Catalyst for Suzuki Coupling Reaction of Unreactive Aryl Chlorides

Dong-Hwan Lee and Myung-Jong Jin*

*Department of Chemical Science and Engineering, Inha University, Incheon 402-751, South Korea, Email: mjjininha.ac.kr

D.-H. Lee, M.-J. Jin, Org. Lett., 2011, 13, 252-255.

DOI: 10.1021/ol102677r (free Supporting Information)


Abstract

A β-Diketiminatophosphane Pd complex acted as a powerful catalyst which allows easy access to Suzuki coupling reactions of less reactive aryl chlorides under mild conditions. A wide range of sterically hindered and deactivated aryl chlorides could be efficiently coupled at a low catalyst loading. Furthermore, this catalytic system also proved to be highly effective in one-pot multiple couplings.

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Key Words

Suzuki Coupling, Biaryls


ID: J54-Y2011-0110