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Oxidation of Organotrifluoroborates via Oxone

Gary A. Molander* and Livia N. Cavalcanti

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States, Email: gmolandrsas.upenn.edu

G. A. Molander, L. N. Cavalcanti, J. Org. Chem., 2011, 76, 623-630.

DOI: 10.1021/jo102208d (free Supporting Information)



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Abstract

The use of Oxone allows the conversion of various aryl-, heteroaryl-, alkenyl-, and alkyltrifluoroborates into the corresponding oxidized products in excellent yields. This method tolerates a broad range of functional groups, and in secondary alkyl substrates it was demonstrated to be completely stereospecific.

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Key Words

Oxone, Phenols, Alcohols, Aldehydes, Organotrifluoroborates


ID: J42-Y2011-0140