Efficient Iron/Copper-Cocatalyzed O-Arylation of Phenols with Bromoarenes
Xiaoyan Liu, Songlin Zhang*
*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science,, Suzhou University, Dushu Lake Campus, Suzhou, 215123, P. R. of China, Email: zhangslsuda.edu.cn
Y. Liu, S. Zhang, Synlett, 2011, 268-272.
Low catalytic amounts of CuI and Fe(acac)3 effectively promote a C-O cross-coupling reaction in the presence of K2CO3 as the base. A serious of diaryl ethers with different substitutents can be synthesized in very good yields. This efficient and economic method is attractive for applications on an industrial scale.
see article for more examples
catalysis, iron, copper, diaryl ethers