Catalyst-Free One-Pot Reductive Alkylation of Primary and Secondary Amines and N,N-Dimethylation of Amino Acids Using Sodium Borohydride in 2,2,2-Trifluoroethanol
Mahmood Tajbakhsh*, Rahman Hosseinzadeh, Heshmatollah Alinezhad, Somayeh Ghahari, Akbar Heydari, Samad Khaksar
*Department of Chemistry, University of Mazandaran, P. O. Box
453, Babolsar 47415, Iran, Email: Tajbaksh
umz.ac.ir
M. Taibakhsh, R. Hosseinzadeh, H. Alinezhad, S. Ghahari, A. Heydari, S. Khaksar, Synthesis, 2011, 490-496.
DOI: 10.1055/s-0030-1258384
Abstract
A simple and convenient procedure enables the reductive alkylation of primary and secondary amines and N,N-dimethylation of amino acids using sodium borohydride as reducing agent in 2,2,2- trifluoroethanol without use of a catalyst or any other additive. The solvent can be revovered and reused.
see article for more examples
Key Words
reductive amination, 2,2,2-trifluoroethanol, sodium borohydride, reductive methylation
ID: J66-Y2011-0310
