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Thermal and Microwave-Assisted Rapid Syntheses of Substituted Imidazo[1,2-a]pyridines Under Solvent- and Catalyst-Free Conditions

Kaushik C. Chunavala, Girdhar Joshi, Eringathodi Suresh, Subbarayappa Adimurthy*

*Central Salt and Marine Chemicals Research Institute (CSIR), G. B. Marg, Bhavnagar 364 002, Gujarat, India, Email:

K. C. Chunavala, G. Joshi, E. Suresh, S. Adimurthy, Synthesis, 2011, 635-641.

DOI: 10.1055/s-0030-1258405

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Thermal and microwave-assisted rapid reactions of aminopyridines and α-bromo-β-keto esters enable the synthesis of highly substituted imidazo[1,2-a]pyridines under solvent-free conditions. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.

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Key Words

aminopyridines, α-bromo-β-keto esters, imidazo[1,2-a]pyridines, green chemistry, microwave synthesis, solvent-free, thermal

ID: J66-Y2011-0400