Synthesis of Carbazoles by Gold(I)-Catalyzed Carbocyclization of 2-(Enynyl)indoles
Chandrasekaran Praveen, Paramasivan Thirumalai Perumal*
*Organic Chemistry Division, Central Leather Research Institute (CSIR Laboratory), Adyar, Chennai 600 020, India, Email: ptperumalgmail.com
C. Praveen, P. T. Perumal, Synlett, 2011, 268-272.
A gold(I)-catalyzed intramolecular hydroarylation of (Z)-2-(enynyl)indoles gives carbazoles in good yields. The requisite (Z)-2-(enynyl)indoles were synthesized stereoselectively by trimethylgallium-promoted, Z-selective Wittig olefination of N-alkylindole-2-carboxaldehydes with propargyl ylides.
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