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Domino Ligand-Free Copper-Catalyzed Synthesis of Polysubstituted Indoles

Md Ashif Ali, Tharmalingam Punniyamurthy*

*Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India, Email:

M. A. Ali, T. Punniyamurthy, Synlett, 2011, 623-626.

DOI: 10.1055/s-0030-1259548


A copper-catalyzed domino reaction of 2-haloanilines and 1,3-dicarbonyl compounds, 1,3-diketones, β-keto esters and β-keto amides under ligand-free conditions provides a simple, general and atom economical process for the synthesis of polysubstituted indoles at moderate temperature.

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Key Words

Cu2O, indoles, cesium carbonate, 1,3-dicarbonyl compounds, 2-haloanilines

ID: J60-Y2011-0610