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Lewis Acid-Mediated Michaelis-Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates

Ganesan Gobi Rajeshwaran, Meganathan Nandakumar, Radhakrishnan Sureshbabu and Arasambattu K Mohanakrishnan*

*Department of Organic Chemistry, School of Chemistry, University of Madras, Guindy Campus Chennai 600 025, Tamil Nadu, India, Email: mohanakrishnanunom.ac.in

G. G. Rajeshwaran, M. Nandakumar, R. Sureshbabu, A. K. Mohanakrishnan, Org. Lett., 2011, 13, 1270-1273.

DOI: 10.1021/ol1029436 (free Supporting Information)


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Abstract

A Lewis acid-mediated Michaelis-Arbuzov reaction of arylmethyl halides and alcohols with triethyl phosphite at room temperature enables a facile preparation of arylmethyl and heteroarylmethyl phosphonate esters in good yields.

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Key Words

Phosphonates, Arbuzov Reaction


ID: J54-Y2011-0650