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Efficient Monophosphorus Ligands for Palladium-Catalyzed Miyaura Borylation

Wenjun Tang*, Santosh Keshipeddy, Yongda Zhang, Xudong Wei, Jolaine Savoie, Nitinchandra D. Patel, Nathan K. Yee and Chris H. Senanayake

*Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, United States, Email: wenjun.tangboehringer-ingelheim.com

W. Tang, S. Keshipeddy, Y. Zhang, X. Wei, J. Savoie, N. D. Patel, N. K. Yee, C. H. Senanayake, Org. Lett., 2011, 13, 1366-1369.

DOI: 10.1021/ol2000556 (free Supporting Information)


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Abstract

In combination with the Bedford Pd precursor, a new biaryl monophosphorus ligand was efficient for palladium-catalyzed Miyaura borylation of sterically hindered aryl bromides at low loadings.

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Key Words

Miyaura Borylation, Arylboronates


ID: J54-Y2011-0730