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Room Temperature, Metal-Free Synthesis of Diaryl Ethers with Use of Diaryliodonium Salts

Nazli Jalalian, Eloisa E. Ishikawa, Luiz F. Silva, Jr. and Berit Olofsson*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden, Email: beritorgan.su.se

N. Jalalian, E. E. Ishikawa, L. F. Silwa, Jr., B. Olofsson, Org. Lett., 2011, 13, 1552-1555.

DOI: 10.1021/ol200265t (free Supporting Information)


Abstract

Mild and metal-free conditions allow a fast and high-yielding synthesis of diaryl ethers - including bulky ortho-substituted diaryl ethers, which are difficult to obtain by metal-catalyzed protocols. Halo-substituents, racemization-prone amino acid derivatives, and heteroaromatics are also tolerated. The methodology is expected to be of high utility in the pharmaceutical industry.

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Key Words

Diaryl Ethers


ID: J54-Y2011-0790