Room Temperature, Metal-Free Synthesis of Diaryl Ethers with Use of Diaryliodonium Salts
Nazli Jalalian, Eloisa E. Ishikawa, Luiz F. Silva, Jr. and Berit Olofsson*
*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden, Email: beritorgan.su.se
N. Jalalian, E. E. Ishikawa, L. F. Silwa, Jr., B. Olofsson, Org. Lett., 2011, 13, 1552-1555.
DOI: 10.1021/ol200265t (free Supporting Information)
Mild and metal-free conditions allow a fast and high-yielding synthesis of diaryl ethers - including bulky ortho-substituted diaryl ethers, which are difficult to obtain by metal-catalyzed protocols. Halo-substituents, racemization-prone amino acid derivatives, and heteroaromatics are also tolerated. The methodology is expected to be of high utility in the pharmaceutical industry.
see article for more examples