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D-Camphor-Derived Triazolium Salts for Enantioselective Intramolecular Stetter Reactions

Zi-Qiang Rong, Yi Li, Gui-Qiu Yang, Shu-Li You*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. of China, Email: slyousioc.ac.cn

Z.-Q. Rong, Y. Li, G.-Q. Yang, S.-L. You, Synlett, 2011, 1033-1037.

DOI: 10.1055/s-0030-1259732 (free Supporting Information)


Abstract

Chiral triazolium salts based on the camphor scaffold are highly efficient catalysts for the asymmetric intramolecular Stetter reaction. With a catalyst loading of 10 mol%, the desired products were obtained in excellent yields with up to 97% ee.

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Key Words

asymmetric catalysis, organocatalysis, camphor, N-heterocyclic carbenes, enantioselectivity, intramolecular Stetter reaction, Chromanones


ID: J60-Y2011-1160