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"Greener" Friedel-Crafts Acylations: A Metal- and Halogen-Free Methodology

Mark C. Wilkinson*

*API Chemistry & Analysis, Product Development, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Email: Mark.C.Wilkinsonhotmail.co.uk

M. C. Wilkinson, Org. Lett., 2011, 13, 2232-2235.

DOI: 10.1021/ol200482s (free Supporting Information)


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Abstract

Methanesulfonic anhydride promotes Friedel-Crafts acylations of aryl and alkyl carboxylic acids. This reagent allows the preparation of aryl ketones in good yield with minimal waste containing no metallic or halogenated components, clearly differentiating it from other available methodologies.

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Key Words

Friedel-Crafts Acylation, Green Chemistry


ID: J54-Y2011-1250