Organic Chemistry Portal

Abstracts

Search:

An Improved Larock Synthesis of Quinolines via a Heck Reaction of 2-Bromoanilines and Allylic Alcohols

Matthew T. Stone*

*Department of Chemistry and Novartis Center for Continuous Manufacturing, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: matthew.stonemerckgroup.com

M. T. Stone, Org. Lett., 2011, 13, 2326-2329.

DOI: 10.1021/ol200579a (free Supporting Information)


Abstract

A modified Larock method enables a one-pot synthesis of substituted quinolines via a Heck reaction of 2-bromoanilines and allylic alcohols followed by dehydrogenation with diisopropyl azodicarboxylate (DIAD).

see article for more examples



Key Words

Quinolines, DIAD


ID: J54-Y2011-1330