Hydrazone-Promoted Sonogashira Coupling Reaction with Aryl Bromides at Low Palladium Loadings
Takashi Mino*, Saori Suzuki, Kiminori Hirai, Masami Sakamoto, Tsutomu Fujita
*Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: tminofaculty.chiba-u.jp
T. Mino, S. Suzuki, K. Hirai, M. Sakamoto, T. Fujita, Synlett, 2011, 1277-1280.
DOI: 10.1055/s-0030-1260535 (free Supporting Information)
The Sonogashira coupling reaction of aryl bromides with various terminal alkynes in DMSO at 125˚C gave internal alkynes in good yields using low catalyst loadings of Pd(acac)2 with hydrazone as a ligand and CuI as the co-catalyst.
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palladium, catalysis, Sonogashira coupling reaction, hydrazone