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Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates

Amruta Joshi-Pangu, Chao-Yuan Wang and Mark R. Biscoe*

*Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, New York 10031, United States, Email: mbiscoeccny.cuny.edu

A. Joshi-Pangu, C.-Y. Wang, M. R. Biscoe, J. Am. Chem. Soc., 2011, 133, 8478-8481.

DOI: 10.1021/ja202769t (free Supporting Information)



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Abstract

A Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides is extremely general for a wide range of electrophiles and generally occurs with little isomerization. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.

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Key Words

Kumada Coupling, Arenes


ID: J48-Y2011-1720