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Direct Benzylic Oxidation with Sodium Hypochlorite Using a New Efficient Catalytic System: TEMPO/Co(OAc)2

Can Jin, Li Zhang, Weike Su*

*Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: pharmlabzjut.edu.cn

C. Jin, L. Zhang, W. Su, Synlett, 2011, 1435-1438.

DOI: 10.1055/s-0030-1260760 (free Supporting Information)


Abstract

The use of NaClO/TEMPO/Co(OAc)2 enabled a benzylic oxidation of alkyl arenes to yield various aromatic aldehydes and ketones in very good yields. The reaction reactivity, selectivity, and scope of the reaction were investigated.


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Key Words

benzylic oxidation, arenes, transition metals, TEMPO, sodium hypochlorite


ID: J60-Y2011-1780