Synthesis of 3-Arylimidazo[1,2-a]pyridines by a Catalyst-Free Cascade Process

Zhiqing Wu, Yinyin Pan, Xiangge Zhou*

*Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064, P. R. of China, Email: zhouxianggescu.edu.cn

Z. Wu, Y. Pan, X. Zhou, Synthesis, 2011, 2255-2260.

DOI: 10.1055/s-0030-1260669

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Abstract

A simple and efficient protocol enables the synthesis of 3-arylimidazo[1,2-a]pyridines by a catalyst-free cascade process from 2-aminopyridine and 1-bromo-2-phenylacetylene or 1,1-dibromo-2-phenylethene in yields up to 86%.

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Key Words

heterocycles, catalyst-free, cascade process, imidazo[1,2-a]pyridines

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ID: J66-Y2011-1900