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Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings

Arkady Krasovskiy and Bruce H. Lipshutz*

*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.

DOI: 10.1021/ol201307y (free Supporting Information)


Abstract

N-Methyimidazole as the key additive enables high yielding stereo- and chemoselective Pd-catalyzed cross-couplings of alkenyl iodides and bromides with primary and secondary alkyl zinc iodides in THF at room temperature.

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Ligand Effects on Negishi Couplings of Alkenyl Halides

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.


Key Words

Negishi Coupling, Alkenes


ID: J54-Y2011-2110