Organic Chemistry Portal

Abstracts

Search:

Highly Selective Reactions of Unbiased Alkenyl Halides and Alkylzinc Halides: Negishi-Plus Couplings

Arkady Krasovskiy and Bruce H. Lipshutz*

*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3822-3825.

DOI: 10.1021/ol201307y


Abstract

N-Methyimidazole as the key additive enables high yielding stereo- and chemoselective Pd-catalyzed cross-couplings of alkenyl iodides and bromides with primary and secondary alkyl zinc iodides in THF at room temperature.

see article for more examples



Ligand Effects on Negishi Couplings of Alkenyl Halides

A. Krasovskiy, B. H. Lipshutz, Org. Lett., 2011, 13, 3818-3821.


Key Words

Negishi Coupling, Alkenes


ID: J54-Y2011-2110