Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines
Nicolas Gouault*, Myriam Le Roch, Adèle Cheignon, Philippe Uriac and Michèle David
*Equipe Produits Naturels, Synthèse et Chimie Médicinale, UMR
6226 Sciences Chimiques de Rennes, Université de Rennes 1, 2 Avenue du Pr Léon
Bernard 35043 Rennes Cedex, France, Email: nicolas.gouault
univ-rennes1.fr
N. Gouault, M. Le Roch, A. Cheignon, P. Uriac, M. David, Org. Lett., 2011, 13, 4371-4373.
DOI: 10.1021/ol201698m (free Supporting Information)
see article for more reactions
Abstract
An enantiospecific syntheses of pyridinones from amino acids via a gold-catalyzed strategy allows excellent stereocontrol during cyclization. This approach provides a straightforward tool for further synthetic applications toward piperidines.
see article for more examples
Key Words
ID: J54-Y2011-2330
