Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges
Timo Leermann, Frédéric R. Leroux* and Françoise Colobert*
*Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université
de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France, Email:
francoise.colobert
unistra.fr, frederic.lerouxunistra.fr
T. Leermann, F. R. Leroux, F. Colobert, Org. Lett., 2011, 13, 4479-4481.
DOI: 10.1021/ol2016252
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Abstract
A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with iPrMgCl·LiCl enables the synthesis of various aryl boronic acids in a straightforward manner in excellent yields at 0°C.
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Key Words
ID: J54-Y2011-2380
