Cu(II)-Catalyzed Intermolecular Amidation of C-Acylimine: A Convenient Access to gem-Diamino Acid Derivatives

Shujie Zhu, Jia Dong, Shaomin Fu, Huanfeng Jiang and Wei Zeng*

*School of Chemistry and Chemical Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou, P. R. China 510641, Email: zengweiscut.edu.cn

S. Zhu, J. Dong, S. Fu, H. Jiang, W. Zeng, Org. Lett., 2011, 13, 4914-4917.

DOI: 10.1021/ol2019955

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Abstract

C-Acylimines undergo intermolecular amidation with amides to produce monoacyl gem-diamino acid derivatives in the presence of Cu(OTf)₂ and PPh₃ under mild conditions. This method provides an efficient access to gem-diamino acid equivalents with good to excellent yields.

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Key Words

1,1-Diamines, Amino Acids

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ID: J54-Y2011-2730